Fenben for humans has been a hot topic in the health community after a video by unlicensed veterinarian Andrew Jones went viral on social media platforms like Facebook and TikTok. The videos alleged that the deworming medication he prescribed to his cancer patient was also effective against human cancer, and it has since become a popular alternative treatment for people suffering from non-small cell lung cancer (NSCLC).
While fenbendazole is widely used as an antiparasitic in veterinary medicine for many different animals including mammals, dogs, birds, fishes, reptiles, etc, its effectiveness in treating human cancer has not been thoroughly studied. However, consuming fenbendazole or its brand name Panacur for long periods of time seems to be well tolerated by most people.
Benzimidazoles such as FZ act by binding with beta-tubulin to disrupt microtubule (MT) polymerization in worm cells. This interferes with the transport of organelles and cellular cyclins, which in turn leads to the inhibition of apoptosis. Moreover, FZ interferes with glucose uptake in cancer cells, causing depletion of glycogen reserves and a decrease in lactate levels.
Researchers tested the effects of fenbendazole on human NSCLC in vitro and found that it induces apoptosis through the disruption of MT dynamics, inactivation of the p53 tumour suppressor gene, and inhibition of glucose uptake by cancer cells. It also affects other important cellular pathways involved in tumorigenesis such as Akt/GSK3, mTOR, Wnt/-catenin signaling, and ERK1/2 pathways. Furthermore, it is advantageous that fenbendazole has multiple cellular targets to avoid the development of resistance, which is often observed with single-target drugs. fenben for humans